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KMID : 0603820110170010047
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 1 p.47 ~ p.53
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Effect of Cnidium officinale Mixture on Recovery Capability of DNCB-induced Allergic Contact Dermatitis in Rat
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Lim Jae-Hwan
Park Young-Mi
Jeong Hyung-Jin
Seo Eul-Won
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Abstract
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This study is aimed to investigate the skin thickness, plasma components, serum IgE level and antioxidant enzymes activities by mixtures of Cnidium officinale, Saururus chinensis, Houttuynia cordata and Glycyrrhiza uralensis on the allergic contact dermatitis of rat induced by 1-chloro-2,4-dinitrochlorobenzene (DNCB). Mixtures reduced the thickness of the skin and removed the dead skin cells compared to the skin of rats treated with DNCB alone. Also, these mixtures down-regulated the contents of lipid and IgE, and reduced the activities of superoxide dismutase and catalase. These results indicate that the mixtures significantly recovered the contact dermatitis induced by DNCB. In conclusion, it is thought that the mixtures could be useful for the allergic contact dermatitis.
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KEYWORD
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Allergic contact dermatitis, Skin, Antioxidant enzymes activities
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